The Music collection, one of the largest in Oregon, consists of over 30,000 music scores and parts for pieces up to 10 players (including instrumental methods books); 225 bound and unbound periodicals (serials, magazines, annuals, etc.); 25,000 books on music; as well as the Music Reference Collection. These materials are located on the third floor of Knight Library. Adjacent to these printed materials are UO Libraries' collection of audio recordings, which are found in the Douglass Room, which also has facilities for listening to recordings.

Particular strengths of the collection include scores and recordings for the compositions of Pacific Northwest composers, especially those from Oregon; music by women composers (both scores and recordings); and a large reference collection of composers' collected editions and monuments of music.

In addition to items housed in the Music area (which is located on the third floor of the Knight Library), microfilm copies of older magazines and journals as well as music resources published only in microfilm form are available in the Microforms Department of the Library.

Archives of musicians and music-related original resources are housed in the Knight Library's Special Collections Department. Of special interest to jazz musicians are the Henry Beau Collection and the Red Nichols Collection.